­
­
­
­

Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/42972/21
    Predicting Pharmacokinetic Properties of Potential Anticancer Agents via Their Chromatographic Behavior on Different Reversed Phase Materials
    01-Jul-2021 Research 2021 : July - September
    Malgorzata Janicka, Anna Mycka, Malgorzata Sztanke, Krzysztof Sztanke

    The Quantitative Structure-Activity Relationship (QSAR) methodology was used to predict biological properties, i.e., the blood–brain distribution (log BB), fraction unbounded in the brain (f u,brain), water-skin permeation (log Kp), binding to human plasma proteins (log Ka,HSA), and intestinal permeability (Caco-2), for three classes of fused azaisocytosine-containing congeners that were considered and tested as promising drug candidates..............

    How to Cite this Article
    Attribution/ CC Compliant Citation: Janicka, Malgorzata, et al. "Predicting Pharmacokinetic Properties of Potential Anticancer Agents via Their Chromatographic Behavior on Different Reversed Phase Materials." International journal of molecular sciences 22.8 (2021): 4257. https://doi.org/10.3390/ijms22084257 http://creativecommons.org/licenses/by/4.0/ Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
    Download Full Text